ROXY EC for MS
Dedicated Electrochemistry/UHPLC System for EC/LC/MS
- Fast metabolic screening of numerous samples
- On-line EC/LC/MS of complex samples
- Compatibility with any MS via contact closure
- Mimicking oxidative stress/damage of proteins, DNA, lipids, etc.
- Simulating nature’s Redox reaction
ROXY EC for MS


Details
With the introduction of the ROXY™ EC/LC System, Antec brings Electrochemistry (EC) to the fingertips of every mass spectrometrist. It makes on-line EC/LC/MS for automated screening of numerous samples available for the first time. The system is based on state-of-the-art fluidics, implementing the ReactorCell™ as part of the autosampler. Furthermore specifically designed liquid handling programs allow for the addition of reagents, making Phase II reactions, i.e., adduct formation, in drug/xenobiotic metabolism easily accessible. Other applications include the studies of covalent drug-protein binding or the studies of reagents, e.g., antioxidants on biopolymers and their biotransformation (patent pending).
The system further comprises a binary high pressure gradient system to assure minimal dwell volume and access to a wide flow rate range, covering conventional HPLC (4.6 mm i.d. columns) down to microbore HPLC (1 mm i.d. columns).
Downloads
Application Notebook
- 210_050_01 - Application Notebook ROXY
Manuals
- 210_7001_01 - User instruction uPrepCell 2.0 High Pressure
- 210_7010_08 - ROXY Potentiostat user manual
- 210_7011_04 - ROXY EC Installation guide
- 210_7013_03 - ROXY EC guideline for SS reducing electrodes
- 210_7014_02 - ReactorCell user manual
- 210_7015_02 - Dialogue software installation and quick start
- 210_7016_02 - ROXY EC system Quick Start Up
- 210_7018_01 - Dialogue for ROXY handson training
- 210_7019_01 - ROXY EC system DEMO start up
- 210_7050_06 - ROXY EC system Installation Requirements
Posters
- 221_070_01 - Online EC MS A Powerful Tool for Fast Prediction of Phase I and II Drug Metabolism
- 221_076_01 - Expanding Role of Electrochemistry Mass Spectrometry in Life Sciences
- 221_077_01 - Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
- 221_078_01 - Identification of electrochemically synthesized metabolites
- 221_079_01 - Insights into Nucleic Acids Oxidation by ElectrochemistryLiquid ChromatographyMass Spectrometry
- 221_090_01 - Degradation of Xenobiotics and Binding to Organic Matter by OnLine EC MS
- 221_105_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals Using an Electrochemical Reactor Cell online with LCMS Rolduc 2014
- 221_106_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism Rolduc 2014
- 221_107_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism ASMS 2014
- 221_108_01 - Controlled Reduction of Disulfide Bonds in Proteins and Peptides Using an Electrochemical Reactor Cell in online LCECMS ASMS 2014
- 221_115_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals ElCheMS2015
- 221_116_01 - Enhanced Pharmaceutical Stability ElCheMS2015
- 221_117_01 - Mimicking Drug Metabolism ElCheMS2015
- 221_118_01 - Electrochem Reduction of Disulfide Bonds ASMS2015
- 221_120_01 - ECHDX for the Analysis of Protein Therapeutics HOS2015
- 221_226_01 - The Application of ElectrochemistryMS to Pharmaceutical Stability Testing and Degradant Synthesis
Applications
ROXY Application Notes
With the introduction of the ROXY™ EC/LC System, Antec brings Electrochemistry (EC) to the fingertips of every mass spectrometrist. It makes on-line EC/LC/MS for automated screening of numerous samples available for the first time. The system is based on state-of-the-art fluidics, implementing the ReactorCell™ as part of the autosampler. Furthermore specifically designed liquid handling programs allow for the addition of reagents, making Phase II reactions, i.e., adduct formation, in drug/xenobiotic metabolism easily accessible. Other applications include the studies of covalent drug-protein binding or the studies of reagents, e.g., antioxidants on biopolymers and their biotransformation (patent pending).
The system further comprises a binary high pressure gradient system to assure minimal dwell volume and access to a wide flow rate range, covering conventional HPLC (4.6 mm i.d. columns) down to microbore HPLC (1 mm i.d. columns).
Application Notebook
- 210_050_01 - Application Notebook ROXY
Manuals
- 210_7001_01 - User instruction uPrepCell 2.0 High Pressure
- 210_7010_08 - ROXY Potentiostat user manual
- 210_7011_04 - ROXY EC Installation guide
- 210_7013_03 - ROXY EC guideline for SS reducing electrodes
- 210_7014_02 - ReactorCell user manual
- 210_7015_02 - Dialogue software installation and quick start
- 210_7016_02 - ROXY EC system Quick Start Up
- 210_7018_01 - Dialogue for ROXY handson training
- 210_7019_01 - ROXY EC system DEMO start up
- 210_7050_06 - ROXY EC system Installation Requirements
Posters
- 221_070_01 - Online EC MS A Powerful Tool for Fast Prediction of Phase I and II Drug Metabolism
- 221_076_01 - Expanding Role of Electrochemistry Mass Spectrometry in Life Sciences
- 221_077_01 - Novel method for efficient reduction of disulfide bonds in peptides and proteins prior MS detection
- 221_078_01 - Identification of electrochemically synthesized metabolites
- 221_079_01 - Insights into Nucleic Acids Oxidation by ElectrochemistryLiquid ChromatographyMass Spectrometry
- 221_090_01 - Degradation of Xenobiotics and Binding to Organic Matter by OnLine EC MS
- 221_105_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals Using an Electrochemical Reactor Cell online with LCMS Rolduc 2014
- 221_106_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism Rolduc 2014
- 221_107_01 - ElectrochemistryMS a Powerful Tool in Drug Metabolism ASMS 2014
- 221_108_01 - Controlled Reduction of Disulfide Bonds in Proteins and Peptides Using an Electrochemical Reactor Cell in online LCECMS ASMS 2014
- 221_115_01 - Controlled Reduction of Disulfide Bonds in Biopharmaceuticals ElCheMS2015
- 221_116_01 - Enhanced Pharmaceutical Stability ElCheMS2015
- 221_117_01 - Mimicking Drug Metabolism ElCheMS2015
- 221_118_01 - Electrochem Reduction of Disulfide Bonds ASMS2015
- 221_120_01 - ECHDX for the Analysis of Protein Therapeutics HOS2015
- 221_226_01 - The Application of ElectrochemistryMS to Pharmaceutical Stability Testing and Degradant Synthesis